论文部分内容阅读
目的:研究地高辛浓度与临床疗效之间的关系.方法:将353例口服地高辛的充血性心衰患者分成3组:有效组、无效组及中毒组.应用放射免疫法(RIA)对其稳态血药浓度进行测定同时观察疗效.结果;平均血药浓度有效组为(1.07±0.50)ng/ml,无效组为(0.97±0.54)ng/ml,中毒组为(2.74±1.35)ng/ml.有效组与中毒组之间血药浓度有显著性差异(P<0.001).有效组与中毒组之间单位剂量(mg·kg~(-1)·d~(-1))有显著性差异(P<0.01).有效组单位剂量为(0.004 0±0.001 2)mg·kg~(-1)·d~(-1),中毒组为(0.004 7±0.001 9)mg·kg~(-1)·d~(-1).结论:地高辛血药浓度的监测可以指导临床医生合理用药、提高疗效、避免或减少不良反应.
Objective: To study the relationship between digoxin concentration and clinical efficacy.Methods: 353 patients with congestive heart failure treated with digoxin were divided into three groups: effective group, ineffective group and poisoning group.Using radioimmunoassay (RIA) (1.07 ± 0.50) ng / ml in the effective group, (0.97 ± 0.54) ng / ml in the invalid group and (2.74 ± 1.35) in the poisoning group ) ng / ml, there was a significant difference between the effective group and the poisoning group (P <0.001). The effective dose of the effective dose group (mg · kg -1 · d -1) ) (P <0.01), and the effective dose was (0.004 0 ± 0.001 2) mg · kg -1 · d -1 in the effective group and 0.004 7 ± 0.001 9 mg Kg ~ (-1) · d ~ (-1) .Conclusion: The monitoring of digoxin plasma concentration can guide clinicians to use medicine rationally to improve curative effect and avoid or reduce adverse reactions.