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目的：探讨牙周炎患者临床治疗中盐酸米诺环素局部用药的效果。方法：选取2013年5月至2015年2月我院收治的牙周炎患者76例，将其随机分成观察组与对照组各为38例，对照组患者以碘甘油加以治疗，观察组患者则以盐酸米诺环素加以治疗。对2组患者临床疗效、不良反应发生率及牙周袋深度、菌斑指数、龈沟出血指数加以对比。结果：本试验中，观察组患者临床治疗总有效率为94.7%，相较于对照组患者的76.3%，差异显著具统计学意义（x2=5.208，P<0.05）；观察组患者经治疗后其PD、PLI、SBI 改善情况显著优于对照组，差异显著具统计学意义（t=6.403，10.374，6.789，8.125，6.292，12.087，P0.05）。结论：将盐酸米诺环素局部应用于牙周炎患者的临床治疗可有效提升临床疗效，改善患者菌斑指数、龈沟出血指数及牙周袋深度等，且无严重不良反应，值得借鉴。“,”Objective: To investigate the clinical treatment of patients with periodontitis and local drug minocycline in effect.Methods: a total of 76 patients with periodontitis may 2013 to 2015 years 2 months in our hospital were randomly divided into observation group and control group the 38 cases, patients in the control group with iodine glycerin treatment, patients in the observation group is to minocycline treatment. The clinical effect, incidence of adverse reaction and the depth of periodontal pocket, plaque index, gingival bleeding index were compared between the 2 groups.Results: in this experiment, to observe the groups of patients with clinical total effective rate was 94.7%, compared to a control group of patients with 76.3%, significant difference was statisticaly significant (P < 0.05) x2=5.208; observation group patients after treatment of the PD, PLI, SBI improvement was significantly beter than that in the control group, significant difference was statisticaly significant (t=6.403, 10.374, 6.789, 8.125, 6.292, 12.087, P 0.05) x2=0.214.Conclusion: the local application of minocycline in treatment of periodontitis patients can effectively improve the clinical efficacy, improve the plaque index, gingival crevicular bleeding index and periodontal pocket depth, and no serious adverse reactions, it is worth learning from.