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在一系列关于头孢菌素类抗生素的结构与反应活性关系的~(13)CNMR谱的研究中,本文作者结合Latamoxef disodium具有高效抗菌活性的特点,研究了它的取代基对β-内酰胺环反应活性的影响,并利用β-内酰胺裂解的假一级反应速率常数k_(obs)和围绕与β-内酰胺环的键特征的δ值以及β-内酰胺羰基IR伸缩振动频率(β-内酰胺uc-o)来阐述取代
In a series of studies on the structure-activity relationship of cephalosporin antibiotics, the study of ~ (13) CNMR spectra of Latamoxef disodium has shown that it has high antibacterial activity against β-lactam ring (Obs) of the pseudo-first-order reaction rate of β-lactam cleavage and the δ value around the bond characteristic of β-lactam ring and the frequency of β-lactam carbonyl IR stretching vibration (β- Lactam uc-o) to illustrate the substitution