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从电离辐射对微血管内皮细胞和淋巴细胞粘附力影响的角度进一步探讨辐射致微循环损伤的机制。方法:采用细胞粘附观察记录装置,观察不同剂量电离辐射作用对培养的内皮细胞和外周血淋巴细胞粘附特性的影响。结果:不同剂量γ射线(60Co)辐射作用内皮细胞(10、15Gy)或淋巴细胞(3、5Gy)后,二者的粘附特性分别发生了明显的改变,表现为二种细胞间的粘附数量明显增多。结论:电离辐射作用下微循环的损伤性变化可能与内皮细胞和淋巴细胞的粘附特性改变有关。
From the perspective of ionizing radiation on the adhesion of microvascular endothelial cells and lymphocytes, we further explored the mechanism of radiation induced microcirculation damage. Methods: The cell adhesion observation and recording device was used to observe the effects of different doses of ionizing radiation on the adhesion characteristics of cultured endothelial cells and peripheral blood lymphocytes. Results: The adhesion characteristics of the two groups changed obviously after irradiation with different doses of 60Co radiation on endothelial cells (10,15Gy) or lymphocytes (3,5Gy), which showed the adhesion between the two kinds of cells The number increased significantly. Conclusion: The damage of microcirculation induced by ionizing radiation may be related to the change of adhesion characteristics of endothelial cells and lymphocytes.