为探讨清开灵注射液的解热机制 ,建立家兔内毒素 (ET)性发热模型 ,观察清开灵对发热家兔体温的影响和下丘脑、脑脊液cAMP及隔区AVP含量的变化。结果显示 ,ET组的ΔT、TRI1、下丘脑cAMP含量、脑脊液cAMP含量、隔区AVP含量显著高于生理盐水组及清开灵注射液 +ET组 ,下丘脑、脑脊液cAMP含量变化与体温变化呈正相关。 4组隔区AVP含量变化亦与体温变化呈正相关。说明清开灵能够抑制ET性发热家兔的体温升高 ,在降低下丘脑、脑脊液cAMP水平的同时促进隔区释放精氨酸加压素 (AVP)。这可能是清开灵解热的重要机制之一。 To investigate the antipyretic mechanism of Qingkailing injection, a rabbit model of endotoxin (ET) fever was established. The effects of Qingkailing on the temperature of rabbits with fever and the changes of cAMP and AVP content in the hypothalamus and cerebrospinal fluid were observed. The results showed that ΔT, TRI1, hypothalamic cAMP content, cAMP cAMP content, septal AVP content in ET group were significantly higher than those in saline group and Qingkailing injection + ET group, positive changes in cAMP content and changes in body temperature were observed in hypothalamus and cerebrospinal fluid. Related. The change of AVP content in the four compartments was also positively correlated with changes in body temperature. It shows that Qingkailing can inhibit the increase of body temperature of ET-induced fever in rabbits, and promote the release of arginine vasopressin (AVP) in the septum while reducing the cAMP level in hypothalamus and cerebrospinal fluid. This may be one of the important mechanisms of the anti-fever of Qing Kai Ling.