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目的观察硝苯地平缓释片联合二甲双胍治疗腹型肥胖性高血压病的临床疗效及其安全性。方法将98例腹型肥胖性高血压病患者随机分为两组:硝苯地平缓释片、二甲双胍联合应用治疗组(A组)49例以及单独应用硝苯地平缓释片治疗组(B组)49例,于治疗12周分别测量体重、身高、血压、空腹血清葡萄糖(FPG)、HbA1c及血脂、肝肾功能等,观察降压疗效以及对心率、血脂、血糖、肾功能的影响。结果 A组显效40例,有效7例,无效2例,总有效率95.9%;B组显效31例,有效8例,无效10例,总有效率80.0%。A组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)水平均显著降低(P<0.05),高密度脂蛋白(HDL-C)水平增高(P<0.05)而B组无明显变化(P>0.05)。结论硝苯地平缓释片、二甲双胍合用对腹型肥胖性高血压治疗疗效理想,对心率、血糖、肾功能无明显影响且有明显降脂和减轻体重作用,是治疗腹型肥胖性高血压病较理想的治疗方案。
Objective To observe the clinical efficacy and safety of nifedipine sustained-release tablets combined with metformin in the treatment of abdominal obesity hypertension. Methods A total of 98 patients with abdominal obesity hypertension were randomly divided into two groups: nifedipine sustained-release tablets, metformin combined application group (A group), 49 cases and nifedipine sustained-release tablets alone group (B group ) For 49 weeks. The body weight, height, blood pressure, fasting serum glucose (FPG), HbA1c, blood lipid, liver and kidney function were measured at 12 weeks of treatment. The effects of antihypertensive effect and heart rate, blood lipid, blood glucose and renal function were observed. Results In group A, 40 cases were markedly effective, 7 cases effective, 2 cases ineffective, and the total effective rate was 95.9%. In group B, 31 cases were markedly effective, 8 cases were effective, 10 were ineffective and the total effective rate was 80.0%. The levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) in group A were significantly lower than those in group A (P0.05), and the levels of high density lipoprotein There was no significant change in group B (P> 0.05). Conclusion Nifedipine sustained-release tablets and metformin are effective in the treatment of abdominal obesity hypertension. They have no significant effect on heart rate, blood glucose and renal function, and have obvious effects of lowering blood fat and reducing body weight. It is an effective treatment for abdominal obesity hypertension The ideal treatment.