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目的观察醋酸奥曲肽注射液在溃疡性上消化道出血中的临床疗效及安全性。方法选取我院2008年4月至2009年12月收治的140例患者,随机分为两组。对照组接受止血等内科综合治疗;研究组在对照组基础上加用醋酸奥曲肽注射液止血治疗,且严密监测用药后24、48 h的止血情况。比较两组临床效果。结果研究组48 h止血总有效率为94.3%远高于对照组的61.4%。研究组患者在治疗过程中并未出现明显不良反应,两组间对48 h有效率进行统计学比较,差异有统计学意义(P<0.05)。结论醋酸奥曲肽注射液治疗溃疡性上消化道出血疗效明显、稳定安全。
Objective To observe the clinical efficacy and safety of octreotide acetate injection in the ulcer upper gastrointestinal bleeding. Methods A total of 140 patients admitted from April 2008 to December 2009 in our hospital were randomly divided into two groups. The control group received comprehensive medical treatment such as hemostasis. The study group was given hemostatic treatment with octreotide acetate injection on the basis of the control group, and the hemostasis was monitored 24 and 48 h after the treatment. The clinical effects of two groups were compared. Results The total effective rate of 48 h in study group was 94.3%, much higher than that in control group (61.4%). There was no significant adverse reactions in the study group during the course of treatment. The 48 h effective rate was statistically compared between the two groups (P <0.05). Conclusion octreotide acetate injection for the treatment of ulcerated upper gastrointestinal bleeding is obvious, stable and safe.