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多种含阳离子的两性药物体内应用和体外培养可引起细胞内的磷脂质沉积。一般认为,磷脂质沉积是一种适应性的反应而非中毒性的表现。主要特征是可逆性的极性磷脂质沉积,在细胞内形成单中心或多中心的板层样的小体。本文主要介绍药物所致磷脂质沉积症的病理学特点,目的是在药物的安全性评价过程中为鉴别磷脂质沉积症提供相关的基础资料。
A variety of cationic amphiphilic drugs in vivo applications and in vitro can cause intracellular phospholipid deposition. It is generally believed that phospholipid deposition is an adaptive response rather than a toxic manifestation. The main feature is the reversible polarity of phospholipid deposition, forming within the cells a single center or polycentrous lamellar body. This article mainly introduces the pathological characteristics of drug-induced phospholipidosis, the purpose is to provide basic information for the identification of phospholipidosis in the safety evaluation of drugs.