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目的：建立精密、快速简便地测定复方氯丙那林片中盐酸氯丙那林、盐酸去氯羟嗪及盐酸溴己新３种成分含量的方法。方法：采用毛细管区带电泳法（ｃａｐｉｌａｒｙｚｏｎｅｅｌｅｃｔｒｏｐｈｏｒｅｓｉｓ，ＣＺＥ），以０．０５ｍｏｌ·Ｌ－１（ｐＨ３．０）磷酸盐缓冲液作运行液，分离电压１８ｋＶ（运行电流１００μＡ～１１０μＡ）。结果：３种成分在８ｍｉｎ～１５ｍｉｎ之内完全达到基线分离，各组分溶液浓度在４０μｇ·ｍｌ－１～２４０μｇ·ｍｌ－１范围内，浓度与峰面积之间呈良好的线性关系。选用甲氧苄氨嘧啶（ＴＭＰ）作内标物，可准确测定３种成分的含量，批内（ＲＳＤ）均小于１．２％（ｎ＝９），３种成分的加样回收率不低于９９．５％，ＲＳＤ均小于１．１％（ｎ＝５）。结论：用ＣＺＥ进行复方氯丙那林片中３种成分的含量测定，准确可靠、方便易行，而药品标准中规定的方法只能定性，不能进行含量测定
OBJECTIVE: To establish a precise and rapid method for the determination of chlorpromazine hydrochloride, dechlorhexine hydrochloride and bromhexine hydrochloride in compound chlorpromazine tablets. Methods: Capillary zone electrophoresis (CZE) was used with 0.05mol·L-1 (pH3.0) phosphate buffer as working solution to separate voltage of 18kV (operating current 100μA ~ 110μA). Results: The three components were completely separated from baseline within 8min ~ 15min. The concentration of each component was in the range of 40μg · ml-1 ~ 240μg · ml-1, and the concentration and peak area showed a good linear relationship. Trimethoprim (TMP) was selected as the internal standard to accurately determine the contents of three components, all within less than 1.2% (n = 9). The recoveries of three components were not low At 99.5%, RSD was less than 1.1% (n = 5). Conclusion: CZE compound chlorpromatin tablets content determination of three components, accurate and reliable, easy and easy, and the drug standard methods can only be qualitative, can not be determined