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目的:调查我院病原菌的分布与耐药趋势,探讨病原菌耐药性与抗菌药物使用强度的相关性,提出临床抗菌药物换药策略。方法:对2008年1-6月临床细菌学标本病原菌的耐药性进行统计分析,结合同期临床抗菌药物的使用强度,分析病原菌耐药率与抗菌药物使用强度的相关性。结果:从临床细菌学标本中共检出病原菌16种,分离细菌总数量756株。病原菌耐药率与抗菌药物使用强度呈正相关。结论:常见病原菌的耐药率与临床使用抗菌药物的强度成正比,对耐药率高的抗菌药物考虑换用其他敏感药物,提高临床抗感染的治愈率。
Objective: To investigate the distribution of pathogens in our hospital and the trend of drug resistance, to explore the correlation between the drug resistance of pathogenic bacteria and the strength of antibacterial drugs, and to propose the strategy of drug-changing clinical antibacterials. Methods: The statistical analysis was made on the drug resistance of clinical bacteriological specimens from January to June in 2008, and the correlation between the drug resistance of pathogenic bacteria and the strength of antibacterials was analyzed. Results: A total of 16 pathogenic bacteria were detected from clinical bacteriological specimens and the total number of bacteria isolated was 756. The rate of pathogen resistance was positively correlated with the strength of antibacterials. Conclusion: The resistance rate of common pathogenic bacteria is directly proportional to the strength of antimicrobial agents in clinical use. Antibacterial agents with high resistance rate may be considered as other sensitive drugs for improving the cure rate of clinical anti-infection.