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目的比较米非司酮不同应用方式治疗子宫内膜异位症的临床效果,探讨较为适合治疗方式。方法随机选择2008年1月至2010年12月本院收治的子宫内膜异位症患者90例,随机分成对照组与观察组各45例,对照组月经周期第一天开始服用接受米非司酮治疗,剂量12.5mg.d-1,共连续用药6个月;观察组于月经中期第十四天开始,1日1次口服米非司酮片6.25mg,连服5d,连续用药6个月经周期。结果对照组治疗当月所有患者均出现闭经,停药后20～25天均恢复月经;观察组大部分患者月经量有所减少,经期缩短1～2d。观察组显效30例、有效13例、无效2例;对照组分别为32例、10例、3例,两组比较疗效无统计学差异(P>0.05)。对照组患者出现低雌激素引起的潮热、烦躁及阴道干涩等症14例、轻度胃肠道反应26例;观察组为7例、3例,观察组低于对照组(P<0.05)。结论黄体初期短程应用小剂量米非司酮拮抗孕激素对减少月经量,缓解痛经症状有较好的疗效,且简单易行,经济方便,值得临床应用。
Objective To compare the clinical effects of different application of mifepristone in the treatment of endometriosis and to explore the more suitable treatment. Methods A total of 90 patients with endometriosis admitted to our hospital from January 2008 to December 2010 were randomly divided into control group and observation group, 45 cases each. Patients in control group were treated with mifepristone Ketone treatment, the dose of 12.5mg.d-1, a total of 6 months continuous medication; observation group in the mid-menstrual fourteenth day, 1 on the 1st mifepristone tablets 6.25mg, and even served 5d, continuous medication 6 Menstrual cycle. Results All patients in the control group had amenorrhea during the month of treatment. Menstruation was resumed after 20 to 25 days after stopping the treatment. Most patients in the observation group had decreased menstrual flow and menstrual period shortened by 1 to 2 days. There were 30 cases in the observation group, 13 cases were effective and 2 cases were ineffective. The control group were 32 cases, 10 cases and 3 cases. There was no significant difference between the two groups (P> 0.05). In the control group, there were 14 cases of hypothalamic, irritable and vaginal dryness caused by low estrogen, 26 cases of mild gastrointestinal reaction, 7 cases in observation group and 3 cases in observation group, which was lower than that in control group (P <0.05) . Conclusion Short-term use of low-dose early luteal phase mifepristone progesterone on reducing menstrual flow, relieve dysmenorrhea symptoms have a good effect, and simple, economical and convenient, it is worth clinical application.