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目的:分析影响肝癌肝移植术后复发受者生存状况的临床病理因素，总结诊治经验。方法:对102例符合“复旦标准”移植后肿瘤复发受者的临床病理特征及诊治方案进行比较(单因素分析)，通过Cox多因素分析得到有独立意义的预后指标。结果:本组受者1、3、5年的总体存活率分别为92.2%、48.6%、34.6%，复发后1、3、5年的带瘤存活率分别为63.2%、31.0%、16.7%，Cox多因素分析示患者年龄、肿瘤可否切除、能否采取以靶向治疗为主的个体化诊治方案是影响总体存活率和带瘤生存率的独立预后因素。结论:肝移植术后肿瘤的复发转移严重影响受者生存，通过积极有效地精准诊治，部分受者仍可获得较满意的预后。“,”Objective:To explore the risk factors influencing the prognosis for patients with hepatocellular carcinoma (HCC) recurrence after liver transplantation and summarize the relevant diagnostic and therapeutic experiences.Methods:The clinicopathological features with diagnosis and treatment plan of 102 recurrent HCC patients fulfilling the Fudan Criteria were compared for survival rate (univariate analysis) and independent prognostic indicators were obtained by Cox multivariate analysis.Results:The 1/3/5-year overall survival rates were 92.2%, 48.6% and 34.6% and the 1/3/5-year survival rates with tumor were 63.2%, 31.0% and 16.7% respectively. Cox regression analysis indicated that patient age, whether tumor can be surgically resected or not and personalized diagnostic & therapeutic plan based upon targeted therapy were independent prognostic factors affecting the overall survival rates and survival rates with tumor.Conclusions:Although HCC recurrence and metastasis after liver transplantation seriously influence patient prognosis, satisfactory outcomes may be obtained for some patients through active, effective and precise managements.