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目的对乳腺癌患者血清维生素B12、叶酸(Folic acid,FA)和同型半胱氨酸(Homocysteine,Hcy)水平进行研究,探讨其与乳腺癌发病风险的关系。方法选择2013年1月-2015年1月衢州市人民医院乳腺癌患者52例作为乳腺癌组,同期体检中心健康体检的健康女性52例作为对照组。测定血清维生素B12、FA和Hcy水平,观察乳腺癌组和对照组血清维生素B12、FA和Hcy水平;乳腺癌组和对照组血清维生素B12、FA和Hcy的相关性;乳腺癌患者中血清维生素B12、FA、Hcy水平和发病风险的关系。结果乳腺癌组血清FA水平低于对照组(P<0.05);乳腺癌组血清Hcy水平高于对照组(P<0.05);乳腺癌组血清维生素B12水平和对照组比较,差异无统计学意义(P>0.05)。乳腺癌组血清FA和Hcy呈负相关(P<0.05),血清维生素B12和FA无相关性(P>0.05),血清维生素B12和Hcy无相关性(P>0.05);对照组血清FA和Hcy呈负相关(P<0.05),血清维生素B12和FA无相关性(P>0.05),血清维生素B12和Hcy无相关性(P>0.05)。乳腺癌患者血清维生素B12和乳腺癌的发病风险之间没有相关性(P>0.05)。乳腺癌患者血清FA和乳腺癌的发病风险之间有显著相关性(P<0.05)。高血清FA人群是低血清FA人群患乳腺癌风险的0.364倍。乳腺癌患者血清Hcy和乳腺癌的发病风险之间有显著相关性(P<0.05)。高血清Hcy人群是低血清Hcy人群患乳腺癌风险的17.231倍。结论乳腺癌患者血清FA水平降低,血清Hcy水平升高,乳腺癌患者的发病风险和血清FA水平负相关,和血清Hcy水平正相关,和血清维生素B12水平没有相关性。
Objective To study the serum levels of vitamin B12, folic acid (FA) and homocysteine (Hcy) in breast cancer patients and explore their relationship with the risk of breast cancer. Methods From January 2013 to January 2015, 52 cases of breast cancer patients in Quzhou People’s Hospital were selected as the breast cancer group, and 52 healthy women in the physical examination center during the same period were selected as the control group. The levels of serum vitamin B12, FA and Hcy in serum were measured. The levels of serum vitamin B12, FA and Hcy in breast cancer and control groups were observed. The correlations between serum vitamin B12, FA and Hcy in breast cancer and control groups were also observed. Serum vitamin B12 , FA, Hcy levels and the incidence of risk. Results The levels of serum FA in breast cancer group were lower than those in control group (P <0.05). The serum Hcy level in breast cancer group was higher than that in control group (P <0.05). There was no significant difference in serum Bcl-2 level between breast cancer group and control group (P> 0.05). There was no significant correlation between serum FA and Hcy in breast cancer (P <0.05), no correlation between serum vitamin B12 and FA, serum vitamin B12 and Hcy (P> 0.05) (P <0.05). There was no correlation between serum vitamin B12 and FA (P> 0.05) and no correlation between serum vitamin B12 and Hcy (P> 0.05). There was no correlation between serum vitamin B12 and the risk of breast cancer in breast cancer patients (P> 0.05). There was a significant correlation between the serum FA of breast cancer patients and the risk of breast cancer (P <0.05). The high serum FA population is 0.364 times the risk of breast cancer in low serum FA populations. There was a significant correlation between the serum Hcy level in breast cancer patients and the risk of breast cancer (P <0.05). The high-serum Hcy population is 17.231 times the risk of breast cancer in low-serum Hcy populations. Conclusions The level of serum FA and the level of serum Hcy in patients with breast cancer are lower than those in patients with breast cancer. The risk of breast cancer patients is negatively correlated with the level of serum FA and positively correlated with serum Hcy level, but not with the level of serum vitamin B12.