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目的探讨慢性乙型肝炎(Chronic Hepatitis B,CHB)患者外周血红细胞分布宽度(RDW)的变化,并分析其与肝脏瞬时弹性测定仪Fibro Touch检测结果的相关性。方法选取CHB患者104例,健康对照者(Healthy Control,HC)123例,采用Sysmex-XN1000全自动血细胞分析仪检测外周血RDW值,采用Fibro Touch检测CHB患者的肝脏硬度值和脂肪衰减参数。结果 CHB组和HC组的RDW值分别为13.79±1.82%和12.95±0.83%,差异有统计学意义(P<0.05)。Spearman相关分析显示,CHB患者RDW与其肝脏硬度值正相关(rs=0.22,P=0.02);与脂肪衰减参数不相关(rs=0.03,P=0.74)。ROC曲线分析显示,RDW预测CHB的曲线下面积(AUC)为0.67;RDW预测肝硬化(肝脏硬度值≥17.5 k Pa)的AUC为0.66。结论 CHB患者RDW显著增高,并与肝脏硬度正相关。
Objective To investigate the distribution of peripheral red blood cell (RDW) in patients with Chronic Hepatitis B (CHB) and analyze its correlation with Fibro Touch transient liver function test. Methods Totally 104 CHB patients and 123 healthy control subjects were enrolled in this study. The peripheral blood RDW was measured by Sysmex-XN1000 automatic hematology analyzer. The liver stiffness and fat decay parameters were measured by Fibro Touch. Results The RDW values of CHB group and HC group were 13.79 ± 1.82% and 12.95 ± 0.83%, respectively, with statistical significance (P <0.05). Spearman correlation analysis showed that RDW in CHB patients was positively correlated with liver hardness (rs = 0.22, P = 0.02), but not with fat decay parameters (rs = 0.03, P = 0.74). ROC curve analysis showed that RDW predicted the area under the curve (AUC) of CHB 0.67; RDW predicted AUC of cirrhosis (liver hardness 17.5 kPa) 0.66. Conclusion The RDW in CHB patients is significantly higher than that in normal controls and positively correlated with liver stiffness.