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目的:探讨阿托伐他汀对初诊2型糖尿病病患者血脂的调节及对早期动脉粥样硬化的防治作用。方法:采用随机、开放、前瞻性研究方法,选择无大血管病变、血脂轻度异常的初诊2型糖尿病患者155例,随机分为阿托伐他汀治疗组(治疗组)80例和非阿托伐他汀治疗组(对照组)75例,在控制血糖、血压的基础上,给予阿托伐他汀治疗,所有患者的治疗期均为12个月。结果:随访12个月后,治疗组空腹血糖(FBS)、餐后2h血糖(2h FBS)、糖化血红蛋白(HbA1C)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高敏C反应蛋白(hs-CRP)、颈总动脉IMT增厚水平明显低于对照组;治疗后,两组之间高密度脂蛋白(HDL-C)无统计学差异;直线相关分析显示治疗组TC、TG、LDL-C和hs-CRP的下降与阿托伐他汀的治疗成正相关,颈总动脉IMT增厚与阿托伐他汀的治疗成负相关。结论:阿托伐他汀对初诊2型糖尿病患者血糖、血脂均有调节作用,并可能具有改善早期动脉粥样硬化、调节炎症反应的作用。
Objective: To investigate the effect of atorvastatin on the blood lipid regulation and early atherosclerosis in newly diagnosed type 2 diabetic patients. Methods: A total of 155 newly diagnosed type 2 diabetic patients without macrovascular disease and mild dyslipidemia were randomly divided into atorvastatin treatment group (n = 80) and non-ata In the statin group, 75 patients were treated with atorvastatin on the basis of controlling blood glucose and blood pressure. All patients were treated for 12 months. RESULTS: After 12 months of follow-up, the fasting blood glucose (FBS), postprandial 2h blood glucose (HbA1C), total cholesterol (TC), triglyceride (TG), low density lipoprotein C, hs-CRP and carotid artery IMT were significantly lower than those of the control group. There was no significant difference of HDL-C between the two groups after treatment The analysis showed that the decrease of TC, TG, LDL-C and hs-CRP in the treatment group was positively correlated with the treatment of atorvastatin. The IMT thickened of the common carotid artery was negatively correlated with the treatment of atorvastatin. Conclusions Atorvastatin has a regulatory effect on blood glucose and blood lipid in newly diagnosed type 2 diabetic patients and may have the effect of improving early atherosclerosis and regulating inflammatory reaction.