1975年,英国剑桥大学Kǒhler和Milstein首先应用细胞融合原理,创立了单克隆抗体(Monoclonal Antibody)技术。由于单克隆抗体纯度高,特异性强、产量大,比常规方法制备的抗血清优越,所以,在生物医学领域中得到了广泛的应用和研究,被公认为免疫学技术的一次革命。 近年来,在皮肤—粘膜病临床上,单克隆抗体亦得到比较多应用,尤其在病理研究 In 1975, Kǒhler and Milstein of the University of Cambridge, UK, first applied the principle of cell fusion to create the monoclonal antibody (Monoclonal Antibody) technology. Due to its high purity, specificity and large yield, the monoclonal antibody is superior to antisera prepared by conventional methods. Therefore, it has been widely used in the field of biomedicine and has been widely recognized as a revolution in immunological technology. In recent years, in the clinical skin-mucosal disease, monoclonal antibodies have also been more applications, especially in pathological studies