高度近视眼因眼轴不断延长引起视网膜脉络膜病变及伴黄斑变性、视网膜下出血、视网膜脱离等并发症 ,最终导致视力丧失 ,已成为主要的致盲眼病之一。但因其发病机制不清楚 ,目前尚无一种确切有效的理想方法防治其形成与发展。因此 ,阐明高度近视的发病机制日益成为生命科学领域? High myopia due to prolonged axial length of the retina caused by choroidal lesions and macular degeneration, subretinal hemorrhage, retinal detachment and other complications, eventually leading to loss of vision, has become one of the major cause of blindness. However, due to its unclear pathogenesis, there is no exact and effective way to prevent its formation and development. Therefore, to clarify the pathogenesis of high myopia increasingly become life sciences?