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目的:观察芪参归汤联合丁苯酞注射液治疗脑梗死的临床疗效。方法:将106例脑梗死患者随机分为治疗组和对照组各53例,两组患者均采用常规基础治疗方法,对照组在常规治疗基础上加用丁苯酞氯化钠注射液,100 m L/次,每日2次;治疗组在对照组治疗基础上加用芪参归汤水煎剂,每次200 m L,早晚分两次服用。两组均治疗2周。比较两组神经功能缺损恢复情况,临床疗效,肿瘤坏死因子α(TNF-α)、神经元特异性烯醇化酶(NSE)、全血黏度、血浆黏度指标水平,以及不良反应情况。结果:治疗组神经功能缺损恢复优于对照组(P<0.05);治疗组患者临床疗效优于对照组(P<0.05);治疗组患者肿瘤坏死因子α(TNF-α)、神经元特异性烯醇化酶(NSE)、全血黏度、血浆黏度改善较对照组更明显(P<0.05);而比较两组治疗后均无不良反应发生。结论:芪参归汤联合丁苯酞注射液治疗脑梗死,临床疗效确切,神经功能缺损恢复明显,安全可靠,值得临床推广。
Objective: To observe the clinical effect of Qishen Gui Tang combined with butylphthalide injection in treating cerebral infarction. Methods: A total of 106 patients with cerebral infarction were randomly divided into treatment group and control group, with 53 cases in each group. The patients in both groups were treated with routine basic treatment. The control group received butylphthalide and sodium chloride injection on the basis of conventional treatment, L / times, twice a day; treatment group in the control group based on the use of Astragalus plus Decoction, 200 m L each time, taking two times in the morning and evening. Both groups were treated for 2 weeks. The recovery of neurological deficit, clinical efficacy, tumor necrosis factor alpha (TNF-α), neuron specific enolase (NSE), whole blood viscosity, plasma viscosity index and adverse reactions were compared between the two groups. Results: The recovery of neurological deficit in the treatment group was better than that in the control group (P <0.05). The clinical efficacy of the treatment group was better than that of the control group (P <0.05). The levels of tumor necrosis factor alpha (TNF- Enolase (NSE), whole blood viscosity, and plasma viscosity were more significantly improved than those in the control group (P <0.05). However, no adverse reactions occurred in both groups after treatment. Conclusion: Qishen Gui Tang combined with butylphthalide injection treatment of cerebral infarction, clinical curative effect, neurological deficit recovery was obvious, safe and reliable, worthy of clinical promotion.