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本文报道用母亲混合初乳中纯化的 SIgA 抑制痢疾杆菌(F_(2a))侵袭力的研究结果。实验分别以与 SIgA 作用过的细菌(实验组)和等量纯菌(对照组)进行比较,并以炎症反应轻重表示侵袭力的程度。结果发现在角、结膜试验中,10只豚鼠的右眼(对照)均有严重炎症,而其左眼(实验)不仅4只完全正常,余6只炎症也较右眼为轻;在肠襻试验中,8只兔回肠病理切片也显示实验肠段的炎症轻于对照段(P<0.05);又在豚鼠痢疾模型试验中,实验组与对照组的动物死亡数分别为6/15和13/15。以上实验均表明细菌经 SIgA 作用后其致病性下降,为了解母乳中 SIgA 的功能及其应用提供了实验依据。
This article reports the results of a study of the inhibition of Shigella dysenteriae (F_ (2a)) with SIgA purified from mixed mothers colostrum. Experiments were compared with SIgA-treated bacteria (experimental group) and the same amount of pure bacteria (control group), and severity of the inflammatory response expressed invasiveness. The results showed that in the angle and conjunctiva experiments, the right eye (control) of 10 guinea pigs had severe inflammation, while the left eye (experiment) not only 4 completely normal, the other 6 inflammation is also lighter than the right eye; In the experiment, pathological sections of the ileum of 8 rabbits also showed that inflammation in the experimental bowel was lighter than that in the control (P <0.05). In the Guinea pig dysentery model experiment, the animal deaths in the experimental group and the control group were 6/15 and 13 / 15. The above experiments show that the pathogenicity of bacteria after SIgA decreased, to provide an experimental basis for understanding the function of SIgA in breast milk and its application.