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目的研究系统性红斑狼疮(SLE)患者的抑郁症状及其与疾病活动性、激素累积剂量和SLE其他因素之间的相关性。方法采用12个月的纵向研究设计,共选定两个观察时间点:疾病活动期与疾病缓解期。选择门诊和住院的62例SLE患者,采用CES-D抑郁自评量表进行问卷调查,同时记录患者的疾病活动度评分(SLEDAI)、激素累积剂量及SLE相关因素。应用Spearman等级相关分析方法分析抑郁与上述指标之间的相关性。结果 SLE疾病活动期30例(48%)SLE患者出现抑郁,缓解期13例(23%),两组比较差异有统计学意义(P<0.01)。大专组以上患者及≤50岁者抑郁的发生率高(P<0.05)。Spearman等级相关分析方法显示,在SLE活动期,抑郁与SLE活动性指数(SLEDAI)(P<0.01)、病程相关(P<0.05)。在SLE稳定期,抑郁与病程、激素总剂量不相关(P>0.05)。结论无论在SLE的活动期还是缓解期,均存在一定程度的抑郁症状。SLE疾病活动可能在抑郁的发生发展中起了一定的作用。
Objective To investigate the depressive symptoms of patients with systemic lupus erythematosus (SLE) and their relationship with disease activity, cumulative dose of hormones and other SLE factors. Methods 12-month longitudinal study design, a total of two selected observation time points: disease activity and disease remission. Sixty-two outpatients and hospitalized SLE patients were surveyed by questionnaire using CES-D depression self-rating scale. SLEDAI, hormone cumulative dose and SLE related factors were also recorded. Spearman rank correlation analysis was used to analyze the correlation between depression and the above indexes. Results SLE patients were depressed in 30 cases (48%) and 13 cases (23%) in remission stage. There was significant difference between the two groups (P <0.01). The incidence of depression was higher in junior college students and those less than 50 years old (P <0.05). Spearman rank correlation analysis showed that depression and SLE activity index (SLEDAI) (P <0.01), duration of illness related to SLE activity (P <0.05). In the stable period of SLE, depression and duration of disease, total hormone dose was not related (P> 0.05). Conclusion There is a certain degree of depressive symptoms in both active and remission stages of SLE. SLE disease activity may play a role in the occurrence and development of depression.