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目的探讨不同年龄晚期非小细胞肺癌(NSCLC)患者的临床特点、治疗方法及预后因素。方法回顾性分析128例晚期NSCLC患者的临床资料,根据年龄分为老年组(86例)和青年组(42例)。分析比较两组患者的临床特点、治疗方法及治疗后的生存状况。结果老年组患者的年龄为(72.10±0.21)岁,青年组患者的年龄为(36.34±0.13)岁。青年组中女性吸烟患者占42.9%,高于老年组女性患者(19.8%),差异有统计学意义(P<0.05)。老年组患者罹患心血管疾病、呼吸系统疾病、消化系统疾病和糖尿病者分别为55.8%、43.0%、46.5%和39.5%,高于青年组(分别为11.9%、19.0%、21.4%和9.5%),差异有统计学意义(P<0.05)。老年组男性患鳞癌比例(26.7%)高于青年组(9.5%),青年组女性腺癌患者比例(33.0%)高于老年组(12.8%),差异有统计学意义(P<0.05)。老年组患者治疗方式以放化疗方式为主(分别为75.6%和16.7%),而青年组患者以手术切除方式为主(分别为83.0%和19.8%),差异有统计学意义(P<0.05)。老年组患者1、3和5年生存率分别为64.3%、47.5%和29.9%,青年组分别为74.3%、53.5%和36.9%,差异均无统计学意义(P>0.05)。结论青年组非小细胞肺癌患者女性多见,肺腺癌所占比例较大,接受手术治疗的比例大。而老年组患者则肺鳞癌所占比例大,伴有其他系统疾病多见。青年和老年非小细胞肺癌患者的预后差异不大。
Objective To investigate the clinical features, treatment and prognostic factors of patients with advanced non-small cell lung cancer (NSCLC) of different ages. Methods The clinical data of 128 patients with advanced NSCLC were retrospectively analyzed. According to their age, they were divided into the elderly group (86 cases) and the young group (42 cases). Analysis of two groups of patients clinical features, treatment and survival after treatment. Results The age of the elderly group was (72.10 ± 0.21) years old, and the age of the young group was (36.34 ± 0.13) years old. The percentage of female smokers in the youth group was 42.9%, which was higher than that in the elderly group (19.8%), the difference was statistically significant (P <0.05). Patients in the elderly group were 55.8%, 43.0%, 46.5% and 39.5% with cardiovascular diseases, respiratory diseases, digestive diseases and diabetes mellitus, respectively, higher than those in the youth group (11.9%, 19.0%, 21.4% and 9.5% ), The difference was statistically significant (P <0.05). The proportion of elderly patients with squamous cell carcinoma (26.7%) was higher than that of young patients (9.5%). The proportion of young women with adenocarcinoma was significantly higher than that of elderly patients (33.0% vs. 12.8%, P <0.05) . The treatment of elderly patients was predominantly radiotherapy and chemotherapy (75.6% and 16.7% respectively), while the younger patients were mainly treated by surgical resection (83.0% and 19.8% respectively) (P <0.05 ). The 1, 3 and 5-year survival rates were 64.3%, 47.5% and 29.9% in the elderly group and 74.3%, 53.5% and 36.9% in the youth group, respectively, with no significant difference (P> 0.05). Conclusion Young women with non-small cell lung cancer are more common in women with lung adenocarcinoma. The proportion of patients receiving surgery is large. The elderly patients with squamous cell carcinoma is a large proportion, with other systemic diseases more common. There is little difference in the prognosis between young and elderly non-small cell lung cancer patients.