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近年来,世界各国儿童和青少年的肥胖发病率逐年增高。而肥胖的一个严重后果是造成胰岛素抵抗。胰岛素抵抗的评价方法包括:瘦素、脂联素、Ghrelin、视黄醇-结合蛋白4等脂肪细胞因子和结合蛋白的测定,高胰岛素正常血糖钳夹试验、微小模型分析的频繁采样静脉血糖耐受试验、空腹血糖和空腹胰岛素比值等生化评价方法。然而,对于儿童,由于许多生化指标分布的正常数据还没有建立,故而没有特异的切点值可用来准确诊断胰岛素抵抗。因此,临床应用时需多种方法综合考虑。
In recent years, the incidence of obesity in children and adolescents around the world has been increasing year by year. A serious consequence of obesity is insulin resistance. Methods for evaluating insulin resistance include: determination of adipocytokines and binding proteins such as leptin, adiponectin, Ghrelin, retinol-binding protein 4, hyperinsulinemic normal glucose clamp test, and frequent sampling of micro-venous blood glucose analysis The test, fasting blood glucose and fasting insulin ratio biochemical evaluation methods. However, in children, no normal cut-off values can be used to accurately diagnose insulin resistance since normal data on the distribution of many biochemical markers have not been established. Therefore, the clinical application of a variety of methods need to be considered.