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利凡诺过去用作消毒防腐药,近几年来配成注射液用于中期引产,颇受临床欢迎。但本品含量测定一般参照利凡诺粉的重量测定法,不够方便。我们参考有关文献试验了容量法,结果还较满意。操作方法:精密量取利凡诺注射液(1%或0.5%)25ml,置100ml 量瓶中,加醋酸钠试液20ml,稀盐酸1.25ml,摇匀,再精密加0.1N 重铬酸钾液50ml,加水3.75ml,不断振摇,混匀,放置1小时后,用干燥滤纸滤过,弃去初滤液20ml,精密量取续滤液50ml,置碘量瓶中,加稀硫酸30ml,碘化钾试液6ml,密塞,暗处放置5分钟,加水50ml,游离出的碘,用0.1N 硫代硫酸钠液滴定,并将滴定的结果用空白试验
Richeno used to be used as antiseptic antiseptic in the past in recent years, dubbed injection for mid-term induction of labor, popular clinical welcome. However, the determination of the content of this product generally refer to the weight of rivanol powder assay, not convenient enough. We refer to the literature test volume method, the results are more satisfied. Method of operation: Precise measure rivanol injection (1% or 0.5%) 25ml, set 100ml flask, add sodium acetate solution 20ml, dilute hydrochloric acid 1.25ml, shake, and then precision plus 0.1N potassium dichromate Liquid 50ml, add water 3.75ml, continue to shake, mix, place 1 hour later, with dry filter paper, discard the initial filtrate 20ml, the precise amount of the filtrate 50ml, set iodine bottle, add dilute sulfuric acid 30ml, potassium iodide 6ml test solution, mousse, dark place for 5 minutes, add water 50ml, free iodine, titration with 0.1N sodium thiosulfate, and the titration results with a blank test