中和法测定复方枸橼酸钠注射液中枸橼酸钠的含量,由于被测物是有机酸的碱金属盐,在滴定过程中没有突跃、终点难以判断。笔者根据有关pH指示剂吸收度比值法的文献报道,改用比色法测定其含量,并进行了下述回收率试验,认为该方法简便,准确,并符合制剂质量控制的要求。 Neutralization method to determine the content of sodium citrate in compound sodium citrate injection. Since the tested substance is an alkali metal salt of organic acid, there is no sudden jump during the titration process, and the end point is difficult to judge. The author according to the ratio of pH indicator absorbance reported in the literature, the colorimetric assay instead of its content, and the following recovery test, that the method is simple and accurate, and in line with the requirements of quality control preparations.