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为探讨内皮素（ＥＴ）在流行性出血热（ＥＨＦ）发病学中的作用及其临床意义，用特异性放射免疫法测定了１２９例ＥＨＦ患者和３０例正常人血浆ＥＴ的浓度。发现ＥＨＦ患者血浆ＥＴ在发热期、低血压休克期、少尿期和移行期均明显高于对照组，少尿期达高峰，多尿晚期恢复正常；同时发现，ＥＴ与ＥＨＦ，急者血清尿调蛋白即Ｔａｍ阶Ｈｏｒｓｆａｌｌ蛋白（ＴＨＰ）和β＿２－微球蛋白均有高度正相关性，且ＥＴ水平越高，病情越重。提示ＥＴ在ＥＨＦ发病中有重要作用，动态监测ＥＴ水平有重要临床意义。
In order to investigate the role of endothelin (ET) in the pathogenesis of epidemic hemorrhagic fever (EHF) and its clinical significance, plasma ET concentrations were measured in 129 EHF patients and 30 normal subjects by specific radioimmunoassay. Found that ET in patients with EHF plasma in the fever, hypotensive shock, oliguria and transitional period were significantly higher than the control group, reached the peak oliguria, polyuria late return to normal; also found that ET and EHF, acute urinary tract Tropsin-like Horsfall protein (THP) and β_2-microglobulin are highly positive correlation, and the higher the ET level, the more serious the disease. It is suggested that ET plays an important role in the pathogenesis of EHF. The dynamic monitoring of ET level has important clinical significance.