患者男,50岁,右手虎口处皮下结节40余年,无痛痒。患者幼年时右手划伤,伤口愈合后在瘢痕处出现一皮下结节。皮损组织病理显示:真皮内见大量大小不一,排列杂乱的神经纤维束。免疫组化显示:增生的神经纤维NSE和S-100阳性表达,边界清楚;周围包绕纤维鞘EMA阳性表达。结合病史诊断为创伤性神经瘤。 Male patient, 50 years old, right hand Tiger mouth subcutaneous nodules more than 40 years, itching. The patient scratches his right hand at an early age and a subcutaneous nodule appears at the scar after the wound is healed. Histopathological lesions showed a large number of different size and arrangement of nerve fiber bundles in the dermis. Immunohistochemistry showed: positive expression of proliferating nerve fibers NSE and S-100, clear boundary; around the fibrous sheath surrounded by EMA positive expression. Combined with the history of diagnosis of traumatic neuroma.