论文部分内容阅读
目的:研究放射性~(125)I粒子组织间植入近距离放疗在体内对人食管鳞癌的疗效及作用机制。方法:建立裸鼠皮下移植性食管鳞癌模型后,对照组A组、假手术组B组、低剂量组C组、中剂量组D组和高剂量组E组,30天观察肿瘤体积计算各组抑瘤率。结果:动物实验中,实验组瘤体积(C组234.5±23.7;D组75.5±15.8;E组65.5±13.4)明显小于对照组(A组823.5±34.2)(P均<0.05),抑瘤率分别为D、E组瘤体积均小于C组(P均<0.05),但D、E组之间无统计学意义(P>0.05);B组(854.4±40.4)和A组瘤体积相比无统计学意义(P>0.05)。结论:~(125)I放射性粒子植入照射体外培养的人食管癌Eca-109细胞,可有效抑制细胞克隆形成率,诱导细胞凋亡,并通过把细胞阻滞在G2/M期而延迟细胞分裂,抑制其增殖能力。~(125)I粒子裸鼠瘤体内植入可有效缩小肿瘤体积,杀伤食管癌细胞。单枚~(125)I粒子的推荐剂量在14.8×106 Bq~29.6×106 Bq之间。
Objective: To study the efficacy and mechanism of radioactive 125 I particles implanted into brachytherapy in patients with esophageal squamous cell carcinoma. METHODS: A nude mice model of subcutaneously implanted esophageal squamous cell carcinoma was established. Control group A, sham group B, low-dose C, middle-dose D, and high-dose E groups were observed for 30 days. Group inhibition rate. RESULTS: In animal experiments, the tumor volume in the experimental group (C 234.5±23.7; D 75.5±15.8; E 65.5±13.4) was significantly less than the control group (A group 823.5±34.2) (P < 0.05). The tumor volume in group D and group E was smaller than that in group C (P<0.05), but there was no significant difference between D and E groups (P>0.05). The tumor volume in group B was (854.4±40.4) compared with that of group A. No statistical significance (P>0.05). CONCLUSION: The implantation of ~(125)I radioactive seeds into human esophageal carcinoma Eca-109 cells in vitro can effectively inhibit the colony formation rate, induce apoptosis, and delay the cells by arresting the cells in the G2/M phase. Divides and inhibits its proliferation. Implantation of ~(125)I particles in nude mice can effectively reduce tumor volume and kill esophageal cancer cells. The recommended dose of a single 125 I particle is between 14.8 x 106 Bq and 29.6 x 106 Bq.