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目的 评价碘酸钾取代碘化钾制作碘盐预防碘缺乏病的效果。方法 将正常 Wistar大鼠和长期低碘繁殖的 Wistar大鼠各分为实验组 (L I,L - L I) ,低碘饲料 ,饮无离子水 ;对照组 (N,L - N ) ,低碘饲料 ,饮 KI水。饲养 3个月后注射 Na1 3 1 IO3 和 Na1 3 1 I观察甲状腺对碘的摄取率。另外 ,给低碘鼠补 KIO3 和 KI 3个月后测尿碘的排出量。结果 经腹腔注射 Na1 3 1 IO3 和 Na1 3 1 I6 h后测得的甲状腺吸碘率 ,在 4组中均显示 :注射 Na1 3 1 I组甲状腺摄碘率高于注射 Na1 3 1 IO3 ,但差异无显著意义。尿碘排出量 ,补 KIO3 组高于 KI组 ,差异也无显著意义。甲状腺吸碘率在实验组 (L I、L - L I)为对照组 (N、L - N )的 8～ 10倍 ;而尿碘排出量实验组为对照组的 1/ 15～ 1/ 5 0。结论 碘酸盐 (KIO3 )和碘化物 (KI)中的碘均能被甲状腺摄取。因此 ,二者防治碘缺乏病具有同样的作用
Objective To evaluate the effect of potassium iodate instead of potassium iodide in iodine deficiency prevention. Methods Normal Wistar rats and long - term low iodine - breeding Wistar rats were divided into experimental group (LI, L - LI), low iodine diet and drinking deionized water. The control group (N, L - , Drink KI water. Three months after feeding, NaI 3 1 IO 3 and Na 1 3 1 I were injected to observe the thyroid uptake of iodine. In addition, low Iodine to make up KIO3 and KI 3 months after the test urinary iodine emissions. Results The iodine uptake rate of thyroid measured by intraperitoneal injection of NaI 3 1 IO 3 and Na 1 3 1 I 6 h all showed that thyroid uptake rate of Na 1 3 1 I group was higher than that of Na 1 3 1 IO 3 injection in 4 groups No significant meaning. Urine iodine output, make KIO3 group higher than the KI group, the difference was not significant. The rate of iodine uptake in thyroid was 8 ~ 10 times higher than that in the control group (L, L - L), while the urinary iodine excretion was 1/15 ~ 1/50 in the control group. Conclusion Iodine (KIO3) and iodine (KI) of iodine can be thyroid uptake. Therefore, the prevention and treatment of iodine deficiency both have the same effect