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细胞凋亡是细胞的程序性死亡,可分为起始与调节和凋亡执行两个大的阶段。细胞凋亡是否发生,取决于起始与调节阶段,一旦进入凋亡执行阶段,则不可回复。细胞凋亡的执行主要依靠caspase-3的活化及其对多种蛋白酶和核酸酶的水解活化;而多种因素参与了细胞凋亡的调节,包括p53基因,p21基因,C-myc基因,NF-кB基因,Fas与FasL、Bcl-2家族的Bcl-2、Bcl-xl、Bad、Bak、Bax和Bid等,caspase家族的caspase-8、caspase-9和caspase-10等,以及较新发现的凋亡抑制因子家族
Apoptosis is a programmed cell death that can be divided into two major stages of initiation and regulation and apoptosis. Whether or not apoptosis occurs depends on the start-up and regulation phases and can not be reversed once the stage of apoptosis has been reached. Apoptosis is mainly dependent on the activation of caspase-3 and its activation of various proteases and nucleases. A variety of factors are involved in the regulation of apoptosis, including p53, p21, C-myc, NF Bcl-2, Bcl-xl, Bad, Bak, Bax and Bid in the Bcl-2 family, caspase-8, caspase-9 and caspase- Apoptosis Inhibitor Family