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一些学者曾用肝穿刺活检研究用氯丙嗪治疗精神病的肝损害,在部份病例中发现门脉区嗜酸性细胞浸润与肝内胆汁郁积。长期用药除上述改变外,曾发现部份病例有肝主质细胞损害,脂肪变性,门脉区纤维化与胆小管增生。但有人用对照组研究,未发现明显差别。作者对36例长期用药4—10年的患者作了肝穿刺,治疗前均无肝病表现(一例幼年曾患黄疸,另一例曾患胆囊炎,但治疗前无肝功能的临床与实验室改变),亦无治疗过程中对药物不能耐受之指征。全
Some scholars have used liver biopsy to study psychiatric liver damage with chlorpromazine, portal eosinophilic infiltration and intrahepatic cholestasis in some cases. Long-term medication in addition to the above changes, it has been found in some cases liver damage of liver cells, steatosis, portal fibrosis and ductal proliferation. However, some people with the control group did not find significant differences. The author of 36 patients with long-term treatment of 4 to 10 years in patients with liver puncture, no liver disease before treatment performance (one case of jaundice in childhood, the other cases had cholecystitis, but no liver function before treatment and laboratory changes) , There is no indication of drug intolerance during treatment. all