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目的研究下咽癌中巨噬细胞移动抑制因子(MIF)与肿瘤侵袭和转移的关系。方法收集下咽癌标本22例,取下咽癌患者的原发灶、颈部淋巴结转移灶及癌旁组织;另取良性病变(声带息肉)标本10例作为对照,采用免疫组化方法检测MIF在各类组织中的表达,并分析其与肿瘤分期、淋巴结转移的关系。结果下咽癌原发灶、转移灶中MIF的表达水平均明显高于癌旁组织及良性病变组织,下咽癌组织中有淋巴结转移组的表达水平高于无淋巴结转移组,临床分期Ⅲ、Ⅳ期的表达水平高于Ⅰ、Ⅱ期。结论 MIF与下咽癌的侵袭和转移有关;肿瘤临床分期越晚,其表达水平越高。
Objective To study the relationship between macrophage migration inhibitory factor (MIF) and tumor invasion and metastasis in hypopharyngeal carcinoma. Methods Twenty-two hypopharyngeal carcinoma specimens were collected and the primary tumor, cervical lymph node metastasis and adjacent tissue were removed from the patients with pharyngeal carcinoma. Ten specimens of benign lesions (vocal cord polyps) were taken as control. The expression of MIF In all kinds of organizations, and analyzed its relationship with tumor staging and lymph node metastasis. Results The expression of MIF in primary hypopharyngeal carcinoma and metastasis was significantly higher than that in paracancer and benign lesions. The expression of MIF in lymph node metastasis was significantly higher than that in non-lymph node metastasis. The clinical stage Ⅲ, The expression level of stage Ⅳ was higher than that of stage Ⅰ and Ⅱ. Conclusions MIF is related to the invasion and metastasis of hypopharyngeal carcinoma. The later the clinical stage of tumor, the higher the expression level of MIF is.