麻醉性镇痛药的拮抗药纳洛酮(Naloxone)已广泛用于拮抗阿片类药引起的呼吸抑制。然而,中枢神经系统和其它组织中存在内源性阿片样物质,这些物质对全身的生理现象具有调节作用,这表明纳洛酮可能有更广泛的治疗作用。此外,一些研究者还证实纳洛酮可以逆转各种麻醉药引起的低血压和镇痛作用,提示麻醉中可释放某种内源性阿片样物质。本文将着重探讨纳洛酮在一些疾病中的应用趋势。 Naloxone, an antagonist of narcotic analgesics, has been widely used to antagonize the respiratory depression caused by opioids. However, the presence of endogenous opioids in the central nervous system and other tissues, which have a regulatory effect on systemic physiology, suggests that naloxone may have a broader therapeutic effect. In addition, some researchers have also confirmed that naloxone can reverse the hypotensive and analgesic effects of various narcotics, suggesting the release of certain endogenous opioids during anesthesia. This article will focus on the trend of application of naloxone in some diseases.