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目的探讨高危型人乳头瘤病毒(HR-HPV)分型检测对宫颈癌及癌前病变筛查的意义。方法选取2011年5月至2016年6月广州医科大学附属第一医院收治的符合标准的3420例研究对象进行HR-HPV分型检测,分析其对宫颈癌及癌前病变筛查的意义。结果 1390例20~29岁患者HR-HPV感染率为12.9%,1460例30~39岁患者HR-HPV感染率为15.0%,360例40~49岁患者HR-HPV感染率为19.4%,210例50~59岁患者HR-HPV感染率为28.6%,可见HR-HPV感染率随年龄增加而升高。不同年龄段HR-HPV感染率比较,差异有统计学意义(P<0.05)。150例行宫颈活检病理学检查的患者中,共检出53例CINⅠ、20例CINⅡ、38例CINⅢ、5例宫颈癌。不同宫颈病变中不同分型HR-HPV感染情况比较,差异有统计学意义(P<0.05)。结论 HR-HPV分型检测对宫颈癌及癌前病变的筛查有非常重要的指导意义。
Objective To investigate the significance of high-risk human papillomavirus (HPV) typing in screening cervical cancer and precancerous lesions. Methods From May 2011 to June 2016, 3420 subjects who met the standard admitted to the First Affiliated Hospital of Guangzhou Medical University were tested for HR-HPV typing, and their significance in screening of cervical cancer and precancerous lesions was analyzed. Results The HR-HPV infection rate in 1390 patients aged 20 to 29 years was 12.9%. The HR-HPV infection rate in 1460 patients aged 30-39 years was 15.0%. The HR-HPV infection rate in 360 patients 40-49 years old was 19.4% Cases of patients aged 50 to 59 HR-HPV infection rate was 28.6%, showing that HR-HPV infection rate increases with age. There were significant differences in HR-HPV infection rates among different age groups (P <0.05). Of the 150 patients who underwent cervical biopsy, 53 CINⅠ, 20 CINⅡ, 38 CINⅢ, and 5 cervical cancer were detected. The different types of HR-HPV infection in different cervical lesions compared with the difference was statistically significant (P <0.05). Conclusion HR-HPV typing detection of cervical cancer and precancerous lesions screening has very important guiding significance.