1966年Embrey指出宫腔内注入前列腺素F_(2α)(PGF_(2α))可使人类子宫肌层收缩。两年后Karim描述前列腺素有产生宫缩的作用。1970年有人首次发表关于前列腺素终止妊娠的报道。在德国也逐渐使用前列腺素终止妊娠。前列腺素的给药途径可采用口服、静脉注射、阴道口以及羊膜腔内与羊膜腔外。开始仅用静脉注射,近来逐渐过渡到应用副作用较小的羊膜腔外或羊膜腔内的给药途 1966 Embrey pointed out that intrauterine injection of prostaglandin F_ (2α) (PGF_ (2α)) can shrink the myometrium. Two years later Karim described prostaglandins as having contractions. The first report on the prostaglandin termination of pregnancy was made in 1970. Gradual use of prostaglandin in Germany also stopped pregnancy. Prostaglandin can be administered by oral route, intravenous injection, vaginal orifice and amniotic cavity and amniotic cavity. Only the beginning of intravenous injection, the recent gradual transition to the application of less side effects of amniotic or amniotic cavity within the drug delivery