环境中的绝大多数外来化合物(包括农药、致突变物及致癌物)进入机体后,都要经历氧化、还原、水解和结合反应这一生物转化过程。使其转变为毒性降低或增强、水溶性增加且易于排出的代谢物。由于生物转化使外来化合物的毒性发生改变,有利于人们认识毒物的作用机理。因此,生物转化过程早已得到了众多学者的关注。其中,微粒体混合功能氧化反应是生物转化的一个重要方面。目前,通过体外重组证明:催化上述反应的微粒体混合功能氧化酶(MFO)系统主要由三部分组成,即细胞色素 P— Most of the foreign environment in the compound (including pesticides, mutants and carcinogens) into the body, have to go through oxidation, reduction, hydrolysis and binding reactions of this biotransformation process. Making it into a metabolite with reduced or increased toxicity, increased water solubility and ease of excretion. As biotransformation changes the toxicity of foreign compounds, it is beneficial to understand the mechanism of action of poison. Therefore, the bioconversion process has long been the concern of many scholars. Among them, microsomal mixed functional oxidation is an important aspect of bioconversion. At present, it is proved by in vitro recombination that the microsomal mixed functional oxidase (MFO) system that catalyzes the above reaction is mainly composed of three parts, that is, the cytochrome P-