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目的 观察流速 容量曲线 (F V)和脉冲振荡 (IOS)检测的相关性和异常检出率符合情况。探讨IOS检测结果判定和临床应用。方法 采用德国Jaeger公司的MastscreenIOS测定仪 ,对 5 0例哮喘患儿进行F V和IOS检测及支气管舒张试验 ,并对两种检测方法各指标进行相关分析及异常符合率比较 ,选择第一秒用力呼气容积 (FEV1)、用力呼气肺活量 (FVC)、5 0 %肺活量最大呼气流量 (MEF50 )、2 5 %肺活量最大呼气流量 (MEF2 5)、呼吸阻抗 (Zrs)、总气道阻力 (R5)、中心气道阻力 (R2 0 )、周边弹性阻力 (X5)、响应频率 (Fres)。结果 支气管舒张试验后FEV1、MEF50 、MEF2 5、FVC较基础有明显的升高 ,而Fres、Zrs、R5、R2 0 、X5均有显著的下降 (P <0 0 0 1) ,表明支气管阻塞症状缓解。且基础和用药后FEV1、MEF50 、MEF2 5、FVC分别与Fres、Zrs、R5、R2 0 、X5均有显著的相关性。当FEV1基本正常 (>80 % ) ,Zrs、R5、X5已有增高 ,提示IOS检测的灵敏度高于FEV1。结论 IOS检测与常规的F V检测有很好的相关性 ,IOS检测操作简单 ,受试者不必做特殊的呼吸动作 ,尤其适合于儿童 ,特别是学龄前儿童
Objective To observe the correlation between the flow velocity capacity curve (F V) and pulse oscillation (IOS) detection and the detection rate of anomaly. To determine the IOS test results and clinical application. Methods The MastscreenIOS analyzer from Jaeger Company of Germany was used to detect FV and IOS in 50 asthmatic children and the bronchodilator test. The correlation between the two methods and the abnormal compliance rate were compared. (FEV1), forced expiratory volume (FVC), 50% maximal expiratory flow (MEF50), 25% maximal expiratory flow (MEF2 5), respiration (Zrs), total airway resistance R5), central airway resistance (R2 0), peripheral elastic resistance (X5) and response frequency (Fres). Results After bronchodilator test, FEV1, MEF50, MEF2 5 and FVC were significantly increased compared with those of basal, while Fres, Zrs, R5, R2 0 and X5 were significantly decreased (P 0 01), indicating bronchial obstruction ease. There was a significant correlation between FEV1, MEF50, MEF2 5, FVC and Fres, Zrs, R5, R2 0 and X5 after basal and administration respectively. When FEV1 is almost normal (> 80%), Zrs, R5, and X5 have been increased, suggesting IOS detection is more sensitive than FEV1. Conclusion The IOS test has a good correlation with the routine F V test. The IOS test is easy to operate. The subjects do not need to do special breathing exercises, especially for children, especially preschool children