论文部分内容阅读
目的观察鲍曼不动杆菌肺部感染的耐药特征及临床药师的干预效果。方法抽选住院治疗的患者80例,均为鲍曼不动杆菌医院获得性肺部感染,取其呼吸道深部痰液进行细菌鉴定及药敏测试,计算菌株耐药率,并由临床药师给予药物干预后进行疗效评价。结果 80株感染菌株对左氧氟沙星耐药率最高,达91.2%;对庆大霉素、头孢曲松、环丙沙星耐药率≥80.0%;对舒巴坦耐药率最低,仅31.2%。临床药师参与药物干预后治疗总有效率57.5%,因重症肺炎死亡18例,占22.5%。结论鲍曼不动杆菌耐药性高,在临床药师的干预下综合患者病情酌情联合用药治疗效果较好,值得推广。
Objective To observe the drug resistance characteristics of Acinetobacter baumannii pulmonary infection and the clinical pharmacist intervention. Methods A total of 80 hospitalized patients were enrolled in this study. All patients were hospital acquired pulmonary infection with Acinetobacter baumannii. The bacteria in the respiratory tract were collected for bacteriological identification and drug susceptibility testing. The clinical drug resistance rate was calculated. Drugs were given by clinical pharmacists Efficacy evaluation after intervention. Results The resistance rate of 80 isolates to levofloxacin was the highest (91.2%). The rates of resistance to gentamicin, ceftriaxone and ciprofloxacin were over 80.0%. The resistance rates to sulbactam were the lowest (31.2%). Clinical pharmacists participate in the total effective rate of treatment after drug intervention 57.5%, 18 cases of severe pneumonia died, accounting for 22.5%. Conclusions Acinetobacter baumannii is highly drug-resistant, and it is worth to popularize the combination of the patients with the disease under the condition of clinical pharmacist.