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目的:探讨老年男性高血压患者雄激素及其受体变化的临床意义。方法:选取老年男性高血压患者43例,另选取健康老年人43例。检测两组体质量指数(BMI)、血糖水平、体脂含量及雄性激素水平,检测的雄性激素包括游离睾酮(FT)、总睾酮(TT)、雌二醇(E2)、性激素结合球蛋白(SHBG)、硫酸脱氢表雄酮(DHEA-s),检测雄激素受体(AR)荧光强度。使用多因素Logistic回归分析高血压组雄性激素水平与雄性激素受体、体质量指数相关性。结果:高血压组的BMI、空腹血糖、高密度脂蛋白(HDL)、胆固醇(CH)、TT等指标与健康组比较,差异具有统计学意义(P<0.05);TT与BMI呈负相关(P=0.0023),TT与AR荧光强度呈正相关(P=0.0360)。结论:血浆雄激素水平对老年高血压发病危险因素进行评估,是评估危险因素新指标。
Objective: To investigate the clinical significance of androgen and its receptor in elderly hypertensive patients. Methods: 43 elderly hypertensive patients and 43 healthy elderly were selected. The body mass index (BMI), blood glucose level, body fat content and androgen concentration were measured in two groups. The testosterone including free testosterone (FT), total testosterone (TT), estradiol (E2), sex hormone binding globulin SHBG), dehydroepiandrosterone sulfate (DHEA-s), and the fluorescence intensity of androgen receptor (AR) was detected. Multivariate logistic regression was used to analyze the association of androgen levels with androgen receptor and body mass index in hypertension group. Results: The indexes of BMI, fasting blood glucose, high density lipoprotein (HDL), cholesterol (CH) and TT in hypertension group were significantly different from those in healthy group (P <0.05); TT was negatively correlated with BMI P = 0.0023). There was a positive correlation between TT and AR fluorescence intensity (P = 0.0360). Conclusion: The level of plasma androgen in evaluating the risk factors of senile hypertension is a new index to evaluate the risk factors.