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目的探讨唇唾液腺和泪腺活检组织的局灶性腺炎在诊断Ｓｊｏｇｒｅｎ综合征的价值。方法对１０５例可疑Ｓｊｏｇｒｅｎ综合征患者进行活检。Ｓｊｏｇｒｅｎ综合征的诊断按照Ｆｏｘ标准，活检诊断按照Ｃｈｉｓｈｏｌｍ－Ｍａｓｏｎ分级和Ｇｒｅｅｎｓｐａｎ分灶标准。结果肌上皮岛和重度淋巴细胞浸润伴生发中心仅出现在泪腺活检组织中。采用双重组织诊断Ｓｊｏｇｒｅｎ综合征较采用单一组织诊断明显有效。结论对可疑Ｓｊｏｇｒｅｎ综合征患者同时行唇唾液腺和泪腺活检可增加诊断的正确性
Objective To investigate the value of focal gonaditis in lip, salivary gland and lacrimal gland biopsy in the diagnosis of Sjogren’s syndrome. Methods 105 patients with suspected Sjogren’s syndrome were biopsied. Diagnosis of Sjogren’s syndrome According to the Fox standard, biopsy diagnosis was based on Chisholm-Mason grading and Greenspan fractional criteria. Results Myoflujial island and severe lymphocytic infiltration associated with germinal center only appeared in the lacrimal gland biopsies. The diagnosis of Sjogren’s syndrome with dual tissue is more effective than single tissue diagnosis. Conclusion Simultaneous lip and salivary gland and lacrimal gland biopsy in patients with suspected Sjogren’s syndrome can increase the diagnostic accuracy