论文部分内容阅读
目的：探讨肿瘤坏死因子（ＴＮＦ）与急性脑血管病（ＡＣＶＤ）的关系。方法：采用酶联免疫吸附法检测了６０例ＡＣＶＤ患者血与脑脊液（ＣＳＦ）中ＴＮＦ水平。结果：ＡＣＶＤ组血及ＣＳＦ中ＴＮＦ水平分别为（２．３９１±０．５１９）μｇ／Ｌ和（３．２９４±１．４１８）μｇ／Ｌ，对照组血及ＣＳＦ中ＴＮＦ水平分别为（１．７６９±０．２７２）μｇ／Ｌ和（１．２３６±０．３９９）μｇ／Ｌ，ＡＣＶＤ组血及ＣＳＦ中ＴＮＦ含量均显著高于对照组（Ｐ＜０．０１，Ｐ＜０．００１）。轻、中、重型ＡＣＶＤ组患者血ＴＮＦ水平分别为（２．１１３±０．４１２）μｇ／Ｌ、（２．４１７±０．３１０）μｇ／Ｌ和（２．９４６±０．４３４）μｇ／Ｌ，ＣＳＦ中ＴＮＦ水平分别为（２．７６３±１．１０８）μｇ／Ｌ、（３．４１７±０．９４２）μｇ／Ｌ和（４．２１９±１．２５３）μｇ／Ｌ，轻、重型组分别与中型组比较，血和ＣＳＦ中ＴＮＦ含量均有显著性差异（Ｐ＜０．０５，Ｐ＜０．０１）。结论：ＴＮＦ参与了ＡＣＶＤ的炎性反应过程，抑制ＴＮＦ产生及抗炎性反应的治疗可能具有潜在的临床价值。
Objective: To investigate the relationship between tumor necrosis factor (TNF) and acute cerebrovascular disease (ACVD). Methods: The levels of TNF in blood and cerebrospinal fluid (CSF) of 60 patients with ACVD were detected by enzyme-linked immunosorbent assay. Results: The levels of TNF in blood and CSF of ACVD group were (2.391 ± 0.519) μg / L and (3.294 ± 1.418) μg / L, respectively. The levels of TNF in blood and CSF of control group were (1 .769 ± 0.272) μg / L and (1.236 ± 0.399) μg / L, respectively. The levels of TNF in serum and CSF in ACVD group were significantly higher than those in control group (P <0.01, P <0.001) ). The blood levels of TNF in patients with mild, moderate and severe ACVD were (2.113 ± 0.412) μg / L, (2.417 ± 0.310) μg / L and (2.946 ± 0.434) μg / (2.763 ± 1.108) μg / L, (3.417 ± 0.942) μg / L and (4.219 ± 1.253) μg / L, respectively, Compared with the medium group, TNF levels in blood and CSF were significantly different (P <0.05, P <0.01). CONCLUSIONS: TNF is involved in the inflammatory reaction of ACVD. It may have potential clinical value to inhibit the production of TNF and the treatment of anti-inflammatory response.