自从在离体实验中发现RNA干扰(RNAi)可以作为潜在的治疗疾病的方法以来,RNAi的这种效果还一直未在动物实验中得到证实。最近中美科学家经过联合研究首次在鼠身上证明,RNAi确实能够保护鼠免受自身免疫性肝病造成的损伤和死亡。 研究人员用RNAi靶向作用于肝细胞上的Fas受体基因(这种基因存在于许多类型的自身免疫性肝病中),受体基因 This effect of RNAi has not been confirmed in animal experiments since RNA interference (RNAi) has been found to be a potential therapeutic approach in vitro. Recently, a joint study between Chinese and American scientists demonstrated for the first time in mice that RNAi can indeed protect mice from the damage and death caused by autoimmune liver disease. Researchers have used RNAi to target the Fas receptor gene on hepatocytes (this gene is present in many types of autoimmune liver disease), the receptor gene