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为研究接骨胶囊促进骨折愈合及抗炎、镇痛的药理作用 ,将实验动物随机分成空白对照组 ,高、低剂量接骨胶囊组和阳性对照药物麝香接骨丹组。家兔造成骨缺损模型 ,用药 4 0天 ,X线和组织学观察骨折愈合 ;用小白鼠腹腔注射醋酸致毛细血管通透性增加和二甲苯致小白鼠耳廓肿胀法观察其抗炎作用 ;用小鼠腹腔注射醋酸扭体反应法观察其镇痛作用。结果表明接骨胶囊能明显促进家兔骨折愈合 ,并具有抗炎、镇痛作用。
To study the pharmacological effects of Jiegu Capsule in promoting fracture healing and anti-inflammatory and analgesic effects, the experimental animals were randomly divided into control group, high-dose, low-dose Jiegu capsule group and positive control drug Ruoxiang Jiegudan group. The model of bone defect was induced in rabbits. The fractures were healed by X-ray and histology at day 40 after treatment. The anti-inflammatory effect was observed by the increase of capillary permeability induced by intraperitoneal injection of acetic acid in mice and the auricular swelling of mice induced by xylene. The mice were intraperitoneally injected with acetic acid writhing to observe its analgesic effect. The results show that Jiegu capsule can significantly promote fracture healing in rabbits and has anti-inflammatory and analgesic effects.