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本文对23例中晚期胃肠道恶性肿瘤患者术后采用大剂量大容积5-Fu 腹腔化疗。全组患者共接受42个疗程、225次腹腔化疗,化疗期间无毒性反应,对肝、肾功能无影响。无肠穿孔、出血、腹腔化脓感染和严重肠粘连等严重并发症。药代动力学比较,腹腔液5-Fu 峰值浓度约是周围静脉血浓度的100倍,并维持了持久恒定浓度梯度差。结果表明,腹腔化疗简便易行,无严重毒副作用和并发症,是治疗中晚期胃肠道恶性肿瘤的一种有前途的辅助措施。其最终临床效果有待进一步研究。
In this article, 23 patients with advanced gastrointestinal malignancy were treated with high-dose, large-volume 5-Fu intraperitoneal chemotherapy. All patients received a total of 42 courses of chemotherapy and 225 intraperitoneal chemotherapy. There was no toxicity during chemotherapy and no effect on liver and kidney function. No serious complications such as intestinal perforation, hemorrhage, peritoneal purulent infection and severe intestinal adhesion. In pharmacokinetics comparisons, the peak concentration of 5-Fu in peritoneal fluid was approximately 100 times that of peripheral venous blood and maintained a constant and constant concentration gradient. The results showed that intraperitoneal chemotherapy was simple and easy, no serious side effects and complications, and it was a promising auxiliary measure for the treatment of advanced gastrointestinal cancer. The final clinical effect is for further study.