本文用Lowry氏法及电泳扫描法测定了老年(34只)及年轻(31只)大鼠血清及脑等六种组织中蛋白质的含量。结果表明,血清、脑、心、肝、肾、肌肉中蛋白质总量及血清白蛋白含量老年组明显低于年轻组(P<0.01),血清γ-球蛋白含量老年组显著高于年轻组(P<0.01),脾中蛋白质总量及血清α_1、α_2、β球蛋白的含量二组间略有差异,但无统计学意义。提示老化与某些组织蛋白含量变化有关。本文还讨论了老化时上述蛋白质变化的机理。 In this paper, the contents of protein in the serum and brain tissues of the aged (34) and young (31) rats were determined by Lowry’s method and electrophoretic scanning. The results showed that the serum protein, brain, heart, liver, kidney, muscle protein content and serum albumin content were significantly lower in the old group than in the young group (P<0.01). The serum γ-globulin content was significantly higher in the old group than in the young group ( P<0.01), the total protein content in the spleen and serum α_1, α_2, and β globulin levels were slightly different between the two groups, but there was no statistical significance. It suggests that aging is related to changes in the content of certain tissue proteins. This article also discusses the mechanism of the above protein changes during aging.