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The weight loss in vivo degradation of poly (lactide-co-glycolide) (PLGA) radiolabeled with 125I was in-vestigated. PLGA with molecular weight (Mw) of 84000(LA/GA = 85/15) were labeled with 125I in the chloroform media by circularly heating and round films of about 15 mm in diameter were formed. The composition and Mw of the 125I-PLGA were characterized by 1H-NMR and viscosimeter. The weight loss of this copolymer in vitro and in vivo degradation was quantified by determining radioactivity of materials. The results indicated that PLGA exhibited sig-nificantly faster degradation in vivo than that of in vitro conditions.
The weight loss in vivo degradation of poly (lactide-co-glycolide) (PLGA) radiolabeled with 125I was in-vestigated. PLGA with molecular weight (Mw) of 84000 (LA / GA = 85/15) were labeled with 125I in the The composition and Mw of the 125I-PLGA were characterized by 1H-NMR and viscosimeter. The weight loss of this copolymer in vitro and in vivo degradation was quantified by determining radioactivity of materials. The results indicates that PLGA exhibited sig-nificantly faster degradation in vivo than that of in vitro conditions.