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目的研究多囊卵巢综合征应用二甲双胍治疗的临床有效性。方法 100例多囊卵巢综合征患者,随机分为实验组和对照组,每组50例。对照组患者给予达英-35进行治疗,实验组患者在对照组的基础上加入二甲双胍进行治疗。观察两组患者治疗前后体质量指数变化,治疗后月经稀发、痤疮、多毛现象等不良反应发生率,并进行比较。结果治疗前两组患者体质量指数比较差异无统计学意义(P>0.05);治疗后,实验组患者体质量指数明显低于对照组,差异具有统计学意义(P<0.05)。实验组患者不良反应发生率为8.00%,低于对照组的32.00%,差异具有统计学意义(P<0.05)。结论应用二甲双胍治疗多囊卵巢综合征临床疗效好,可在临床应用。
Objective To study the clinical efficacy of metformin in patients with polycystic ovary syndrome. Methods 100 cases of PCOS patients were randomly divided into experimental group and control group, 50 cases in each group. Patients in the control group were treated with up to -35, and patients in the experimental group were treated with metformin on the basis of the control group. The changes of body mass index before and after treatment, the incidence of postmenopausal hair loss, acne and hirsutism were observed and compared between the two groups. Results There was no significant difference in body mass index between the two groups before treatment (P> 0.05). After treatment, the body mass index of the experimental group was significantly lower than that of the control group (P <0.05). The incidence of adverse reactions in the experimental group was 8.00%, which was lower than that in the control group (32.00%), the difference was statistically significant (P <0.05). Conclusion Metformin in the treatment of polycystic ovary syndrome clinical curative effect is good, can be in clinical application.