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目的观察利多卡因联合硫酸镁防治蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的疗效。方法42例SAH患者,利多卡因联合硫酸镁治疗组20例,尼莫地平组22例。两组均采用相同的基础治疗和对症处理。利多卡因联合硫酸镁组为利多卡因200mg加入生理盐水250m l静滴,2次/d,25%硫酸镁10m l加入5%葡萄糖液250m l静滴,2次/d,连用14d。尼莫地平组为尼莫地平10mg静滴,2次/d,连用14d。应用TCD监测颅内血管情况。结果第15天时利多卡因联合硫酸镁治疗组与尼莫地平治疗组在防治SAH后CVS的疗效相近。结论其具有较高的卫生经济学价值。
Objective To observe the curative effect of lidocaine and magnesium sulfate on cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH). Methods Forty-two patients with SAH were treated with lidocaine plus magnesium sulfate in 20 cases and nimodipine in 22 cases. Both groups used the same basic treatment and symptomatic treatment. Lidocaine combined magnesium sulfate group for lidocaine 200mg added saline 250ml intravenous drip, 2 times / d, 25% magnesium sulfate 10ml added 5% glucose solution 250ml intravenous infusion, 2 times / d, once every 14d. Nimodipine group nimodipine 10mg intravenous infusion, 2 times / d, once every 14d. Application of TCD to monitor intracranial vascular conditions. Results On the 15th day, the efficacy of lidocaine plus magnesium sulfate in combination with nimodipine was similar to that of CVS after SAH. Conclusion It has high health economics value.