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已知氟中毒是一种可影响骨骼系统和牙齿结构及功能的慢性进行性退化性疾病,还可使肌腱韧带钙化,并可扩展到肌肉束。氟离子对钙具有很强的亲合力。骨骼肌中含钙水平较高而使其对氟化物的毒性作用更敏感。由于肌红蛋白含量的降低,而使肌肉变得苍白。氟化物还可增强肌膜的渗透性,由于肌细胞膜渗透性增高,血流中的肌酸酐激
It is known that fluorosis is a chronic, progressive degenerative condition that affects the structure and function of the skeletal system and teeth. It can also calcify the tendon ligament and extend to the muscle bundle. Fluoride ions have a strong affinity for calcium. Higher levels of calcium in skeletal muscle make them more sensitive to the toxic effects of fluoride. Myoglobin becomes pale due to a decrease in myoglobin content. Fluoride can also enhance the permeability of the muscle membrane, due to increased permeability of muscle cell membrane, creatinine in the blood flow shock