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糖尿病肾病(Diabetic Nephyropathy,DN)的发生与发展是多因素综合作用的结果,其中糖代谢紊乱、肾脏血流动力学的改变、多种细胞因子以及遗传背景均起非常重要作用。据报道DN的发病人数占糖尿病患者的35%~40%,据美国肾脏资料系统(USRDS)1992年新发生终末期肾脏病(end-stage renal disease,ESRD)54 586例,其中糖尿病19 790例,占36.25%,超过了高血压和肾炎。因此,糖尿病肾病的治疗和预防成为当务之急。1 糖尿病肾脏病的发展阶段按丹麦Mogensen等的标准,将糖尿病肾病发展分为五期:Ⅰ期:糖尿病肾病初期。肾脏肥大,功能亢进期,亦称肾小球高滤过期。此期特点为肾脏体积增大,肾血流量和肾小球滤过率
The occurrence and development of diabetic nephropathy (DN) are the result of multifactorial combination of factors. Among them, the disorder of glucose metabolism, the changes of renal hemodynamics, various cytokines and genetic background play a very important role. It has been reported that the number of DN patients accounts for 35% to 40% of patients with diabetes. According to the USRDS 54,586 new cases of end-stage renal disease (ESRD) in 1992, 19,790 cases of diabetes , Accounting for 36.25%, more than high blood pressure and nephritis. Therefore, the treatment and prevention of diabetic nephropathy has become a top priority. 1 stage of development of diabetic nephropathy According to the Danish Mogensen and other criteria, the development of diabetic nephropathy is divided into five phases: stage Ⅰ: early stage of diabetic nephropathy. Renal hypertrophy, hyperthyroidism period, also known as glomerular hyperfiltration. This period features kidney volume increase, renal blood flow and glomerular filtration rate