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目的探讨细胞周期抑制蛋白p27kip1在胆管癌组织中的表达及与胆管癌各项临床病理特征的关系。方法采用免疫组化法检测43例胆管癌组织及10例伴慢性胆管炎的胆管壁组织中p27kip1的表达,结合临床病理资料进行回顾性分析。结果①p27kip1在胆管癌组织中的阳性表达率为30.23%(13/43),而在伴慢性炎症的胆管组织中阳性表达率为80.00%(8/10),差异有统计学意义(P<0.05)。②p27kip1蛋白表达与胆管癌的分化程度及临床分期呈显著相关(P<0.05)。结论胆管癌中p27kip1蛋白低表达可能与胆管癌的发生发展有关,检测p27kip1的表达对胆管癌的预测有一定的参考价值。
Objective To investigate the expression of cyclin inhibitor p27kip1 in cholangiocarcinoma and its relationship with clinicopathological features of cholangiocarcinoma. Methods Immunohistochemistry was used to detect the expression of p27kip1 in 43 cases of cholangiocarcinoma and 10 cases of chronic cholangitis with chronic cholangitis. The clinical pathological data were used for retrospective analysis. Results The positive expression rate of p27kip1 in cholangiocarcinoma tissues was 30.23% (13/43), while the positive expression rate in chronic bile duct tissues with chronic inflammation was 80.00% (8/10). The difference was statistically significant (P<0.05). ). The expression of 2p27kip1 protein was significantly correlated with the differentiation degree and clinical stage of cholangiocarcinoma (P<0.05). Conclusion The low expression of p27kip1 in cholangiocarcinoma may be related to the occurrence and development of cholangiocarcinoma. The detection of p27kip1 expression has certain reference value for the prediction of cholangiocarcinoma.